We use Nuclear Magnetic Resonance (NMR) spectroscopy as well as other biophysical and molecular biology techniques to study of membrane and soluble proteins.

Hemoglobin: Our lab current interest is in the molecular mechanisms that govern hemoglobin structure, oxidative stability, and drug interactions, with a focus on applications in sickle cell disease (SCD) and other hemoglobinopathies. This project integrates biophysical techniques such as nuclear magnetic resonance spectroscopy (NMR) with molecular assays to reveal how hemoglobin structure, oxidation, and drug interactions influence disease-relevant pathways. Our work aims to contribute to better structure-based design of hemoglobin modulators that can improve clinical outcomes for patients with hemoglobinopathies.